Jaime Mella
Química Medicinal.
- Universidad: Universidad de Valparaíso
- Profesor: De claustro
- E-mail: jaime.mella@uv.cl
- Año en que ingreso al programa: 2012
- Dedicación estimada: 3 horas semanales
- Grado Máximo: Doctor en Química / Pontificia Universidad Católica de Chile
- Año de graduación: 2012
- Tesis dirigidas en los últimos 10 años: 7 pregado y 3 de postgrado en curso
Líneas de investigación: Química Medicinal. Síntesis Orgánica (Heterociclos): estudios QSAR, estudios docking, diseño de moléculas bioactivas.
Publicaciones indexadas en los últimos 10 años:
- Espinosa-Bustos, C.; Mella, J.; Soto-Delgado, J.; Salas, C. O.State of the art of Smo antagonists for cancer therapy: advances in the target receptor and new ligand structures. Future Med Chem, 11(6), 615-636, 3,969, 10.4155/fmc-2018-0497, 2019.
- Mellado, M.; Madrid, A.; Reyna, M.; Weinstein-Oppenheimer, C.; Mella, J.; Salas, C. O.; Sánchez, E.; Cuellar, M. Synthesis of chalcones with antiproliferative activity on the SH-SY5Y neuroblastoma cell line: Quantitative Structure–Activity Relationship Models. Med. Chem. Res., 27 (11), 2414–2425, 1,6071,607, 10.1007/s00044-018-2245-2, 2018.
- Mellado, M.; Madrid, A.; Martínez, Ú.; Mella, J.; Salas, C. O.; Cuellar, M.Hansch’s analysis application to chalcone synthesis by Claisen–Schmidt reaction based in DFT methodology, Chem. Pap. 0,963. 10.1007/s11696-017-. 0316-3. 2018.
- Lorca, M.; Morales-Verdejo, C.; Vasquez-Velasquez, D.; Andrades-Lagos, J.; Campanini-Salinas, J.; Soto-Delgado, J.; Recabarren-Gajardo, G.; Mella, J. Structure-Activity Relationships Based on 3D-QSAR CoMFA/CoMSIA and Design of Aryloxypropanol-Amine Agonists with Selectivity for the Human β3-Adrenergic Receptor and Anti-Obesity and Anti-Diabetic Profiles. Molecules. 23(5), 1191, 3,098, 10.3390/molecules23051191, 2018.
- Lopez-Lira, C.; Alzate-Morales, J. H.; Paulino, M.; Mella-Raipan, J.; Salas, C. O.; Tapia, R. A.; Soto-Delgado, J.Combined molecular modelling and 3D‐QSAR study for understanding the inhibition of NQO1 by heterocyclic quinone derivatives. Chem. Biol. Drug. Des. 91(1), 29-38, 2,328, 10.1111/cbdd.13051. 2018.
- Campanini-Salinas, J.; Andrades-Lagos, J.; Mella-Raipan, J.; Vasquez-Velasquez, D. Novel Classes of Antibacterial Drugs in Clinical Development, a Hope in a Post-antibiotic Era. Curr Top Med Chem. 18 (14), 1188-1202, 3,374, 10.2174/1568026618666180816162846. 2018.
- Campanini-Salinas, J.; Andrades-Lagos, J.; Gonzalez Rocha, G.; Choquesillo-Lazarte, D.; Bollo Dragnic, S.; Faundez, M.; Alarcon, P.; Silva, F.; Vidal, R.; Salas-Huenuleo, E.; Kogan, M.; Mella, J.; Recabarren Gajardo, G.; Vasquez-Velasquez, D.A new kind of quinonic-antibiotic useful against multidrug-resistant S. aureus and E. faecium infections. Molecules. 23(7), 1776, 3,098, 10.3390/molecules23071776. 2018.
- Cañete-Molina, Á.; Espinosa-Bustos, C.; González-Castro, M.; Faúndez, M.; Mella, J.; Tapia, R. A.; Cabrera, A. R.; Brito, I.; Aguirre, A.; Salas, C. O.Design, synthesis, cytotoxicity and 3D-QSAR analysis of new 3, 6-disubstituted-1, 2, 4, 5-tetrazine derivatives as potential antitumor agents. Arabian J. Chem. In Press, 2,969, 10.1016/j.arabjc.2017.04.002. 2017.
- Romero-Parra, J.; Chung, H.; Tapia, R. A.; Faundez, M.; Morales-Verdejo, C.; Lorca, M.; Lagos, C. F.; Di Marzo, V.; David Pessoa-Mahana, C.; Mella, J. Combined CoMFA and CoMSIA 3D-QSAR study of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor. Eur. J. Pharm. Sci. 101, 1-10., 3,466, 10.1016/j.ejps.2017.01.037. 2017.
- Mella, J.; Villegas, F.; Morales-Verdejo, C.; Lagos, C. F.; Recabarren-Gajardo, G. Structure-activity relationships studies on weakly basic n arylsulfonylindoles with an antagonistic profile in the 5-HT6 receptor. J. Mol. Struct. 1139, 362-370, 2,011, 10.1016/j.molstruc.2017.03.067. 2017.
Proyectos de investigación en los últimos 10 años:
- FONDECYT 1191330. «Synthesis of new brassinosteroid analogs with structural changes in the side chain. Evaluation of growth promoting effect and in silico structure-activity studies». 2019-20223. Coinvestigador.
- FONDECYT de Inicio N°11130701, “Rational design, synthesis, biological evaluation and quantitative structure-activity relationships of novel ß3-AR ligands” 2013-2017. Investigador responsable.
- FONDECYT Regular N°1150121, “Synthesis, binding mode prediction, biological evaluation and SAR analysis of benzoimidazole-based modulators of the endocannabinoid system” FONDECYT Regular N°1150121, 2015-2019. Coinvestigador.
